Overview

  • Product name
    Carboplatin
  • Description
    Antitumor agent; blocks DNA replication and transcription. Cisplatin analog.
  • Biological description
    Antitumor agent. Forms platinum-DNA adducts blocking DNA replication and transcription. Displays lower nephrotoxicity than analog, cisplatin (ab141398). Active in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    cis-Diamine(1,1-cyclobutanedicarboxylato)platinum (II)
  • Molecular weight
    371.25
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C6H12N2O4Pt
  • CAS Number
    41575-94-4
  • PubChem identifier
    426756
  • Storage instructions
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 25 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Souza CM  et al. Carboplatin delays mammary cancer 4T1 growth in mice. Pathol Res Pract 209:24-9 (2013). Read more (PubMed: 23164716) »
  • Mlcouskova J  et al. Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding. J Biol Inorg Chem 17:891-8 (2012). Read more (PubMed: 22638735) »
  • Thomas JP  et al. High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity. Mol Pharmacol 70:23-9 (2006). Read more (PubMed: 16569706) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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