Anti-Carboxymethyl Lysine antibody [CMS-10] (ab30922)
Key features and details
- Mouse monoclonal [CMS-10] to Carboxymethyl Lysine
- Suitable for: ELISA, IHC-Fr, IHC-P
- Reacts with: Species independent
- Isotype: IgG1
Overview
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Product name
Anti-Carboxymethyl Lysine antibody [CMS-10]
See all Carboxymethyl Lysine primary antibodies -
Description
Mouse monoclonal [CMS-10] to Carboxymethyl Lysine -
Host species
Mouse -
Tested applications
Suitable for: ELISA, IHC-Fr, IHC-Pmore details -
Species reactivity
Reacts with: Species independent -
Immunogen
N epsilon (Carboxymethyl) Lysine (CML) conjugated to KLH.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Proclin 150
Ascites in stabilized buffer, containing 50% Block Ace (Casein-containing solution) and 0.1% ProClin as a preservative. -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
CMS-10 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab30922 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use a concentration of 0.1 - 0.5 µg/ml.
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IHC-Fr |
Use a concentration of 2 µg/ml.
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IHC-P | (1) |
Use at an assay dependent concentration.
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Notes |
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ELISA
Use a concentration of 0.1 - 0.5 µg/ml. |
IHC-Fr
Use a concentration of 2 µg/ml. |
IHC-P
Use at an assay dependent concentration. |
Target
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Relevance
N epsilon carboxymethyl lysine (CML or Carboxymethyl Lysine) is formed by the non enzymatic Schiff base reaction of glucose with proteins, followed by an Amadori rearrangement and oxidation that leaves only a carboxymethyl group attached to the lysine. The levels of CML adducts accumulate over time and have been used as an indicator of both serum glucose levels and oxidative protein damage. Elevated serum CML modified proteins have been associated with diabetes and may contribute to diabetic retinopathy, nephropathy and angiopathy. -
Alternative names
- CML antibody
- N Epsilon (Carboxymethyl) Lysine antibody
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab30922 has been referenced in 2 publications.
- Portal-Núñez S et al. Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice. J Gerontol A Biol Sci Med Sci 71:290-9 (2016). PubMed: 26386012
- de la Maza MP et al. Weight increase is associated with skeletal muscle immunostaining for advanced glycation end products, receptor for advanced glycation end products, and oxidation injury. Rejuvenation Res 11:1041-8 (2008). IHC-P . PubMed: 19086911