Anti-Carboxypeptidase B2 antibody [13D5] (ab14756)

Overview

  • Product nameAnti-Carboxypeptidase B2 antibody [13D5]
    See all Carboxypeptidase B2 primary antibodies
  • Description
    Mouse monoclonal [13D5] to Carboxypeptidase B2
  • Tested applicationsSuitable for: ELISA, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab14756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [13H4] to Carboxypeptidase B2 (HRP) (ab14757) and Mouse monoclonal [19E2] to Carboxypeptidase B2 (HRP) (ab14767). Can be used as Capture antibody. Best recommended pair: Ab14756 as Capture and Ab14767 as Detection.

Target

  • RelevanceThis protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues; pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5 – 10 µg/ml. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.
  • Cellular localizationSecreted
  • Database links
  • Alternative names
    • 1110032P04Rik antibody
    • 4930405E17Rik antibody
    • bA139H14.2 antibody
    • Carboxypeptidase B like protein antibody
    • Carboxypeptidase U antibody
    • CarboxypeptidaseB2 antibody
    • CarboxypeptidaseU antibody
    • CP B2 antibody
    • CPB 2 antibody
    • CPB2 antibody
    • CPU antibody
    • PCPB antibody
    • Plasma carboxypeptidase B antibody
    • Plasma carboxypeptidase B2 antibody
    • Procarboxypeptidase B antibody
    • Procarboxypeptidase R antibody
    • Procarboxypeptidase U antibody
    • TAFI antibody
    • Thrombin activable fibrinolysis inhibitor antibody
    • Thrombin activatable fibrinolysis inhibitor antibody
    see all

Anti-Carboxypeptidase B2 antibody [13D5] images

  • Titration curves of carboxypeptidase B2 in plasma using antibody pair; capture ab14756, 200ng/well and HRPconjugated antibody ab14757. Incubated at room temperature.

References for Anti-Carboxypeptidase B2 antibody [13D5] (ab14756)

ab14756 has not yet been referenced specifically in any publications.

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