Overview

  • Product name
  • Description
    Rabbit polyclonal to CARD8
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, conjugated to KLH, from the C terminal region of Human CARD8.

  • Positive control
    • Human spleen tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99.98% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115313 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 µg/ml. Predicted molecular weight: 49 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

Target

  • Function
    Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • Tissue specificity
    High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.
  • Sequence similarities
    Contains 1 CARD domain.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptotic protein NDPP 1 antibody
    • Apoptotic protein NDPP1 antibody
    • CARD 8 antibody
    • CARD inhibitor of NF kappa B activating ligand antibody
    • CARD inhibitor of NF kappaB activating ligand antibody
    • CARD inhibitor of NF kappaB activating ligands antibody
    • CARD-inhibitor of NF-kappa-B-activating ligand antibody
    • CARD8 antibody
    • CARD8_HUMAN antibody
    • CARDINAL antibody
    • Caspase recruitment domain containing protein 8 antibody
    • Caspase recruitment domain family member 8 antibody
    • Caspase recruitment domain protein 8 antibody
    • Caspase recruitment domain-containing protein 8 antibody
    • DACAR antibody
    • Dakar antibody
    • DKFZp779L0366 antibody
    • FLJ18119 antibody
    • FLJ18121 antibody
    • KIAA0955 antibody
    • MGC57162 antibody
    • NDPP 1 antibody
    • NDPP antibody
    • NDPP1 antibody
    • TUCAN antibody
    • Tumor up regulated CARD containing antagonist of CASP9 antibody
    • Tumor up regulated CARD containing antagonist of caspase 9 antibody
    • Tumor up-regulated CARD-containing antagonist of CASP9 antibody
    • tumor up-regulated CARD-containing antagonist of caspase nine antibody
    • Tumor upregulated CARD containing antagonist of CASP9 antibody
    see all

Images

  • ab115313 at 5ug/ml staining CARD8 in Human spleen tissue by immunohistochemistry (FFPE). After primary incubation slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

References

ab115313 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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