Overview
- Product nameAnti-cardiac Troponin T antibodySee all Cardiac Troponin T primary antibodies ...
- DescriptionMouse monoclonal to cardiac Troponin T
- SpecificityThis antibody reacts with cardiac troponin T. Cross-reactivity with human skeletaltroponin T is less than 0.1%.
- Tested applicationsELISA more details
- Species reactivityReacts with: Human
- Immunogen
Purified human cardiac troponin T.
Properties
- FormLiquid
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPBS, pH 7.2, sodium azide, 0.1%
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Concentration information loading... - PurityProtein G purified
- Clonality Monoclonal
- IsotypeIgG1
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab998 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| AP | |
| ELISA |
ELISAtiter = 1: 5,000,000.
Target
- FunctionTroponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
- Tissue specificityHeart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.
- Involvement in diseaseDefects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2) [MIM:115195]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D) [MIM:601494]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3) [MIM:612422]. Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. - Sequence similaritiesBelongs to the troponin T family.
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Database links
- Entrez Gene: 7139 Human
- Omim: 191045 Human
- SwissProt: P45379 Human
- Unigene: 533613 Human
Target information above from: UniProt accession
P45379
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- Cardiac muscle troponin T antibodyCardiomyopathy dilated 1D (autosomal dominant) antibodyCardiomyopathy hypertrophic 2 antibody
- CMD1D antibodyCMH2 antibodyCMPD2 antibodycTnT antibodyLVNC6 antibodyMGC3889 antibodyOTTHUMP00000033864 antibodyOTTHUMP00000033865 antibodyOTTHUMP00000033866 antibodyOTTHUMP00000033867 antibodyOTTHUMP00000033870 antibodyOTTHUMP00000218095 antibodyRCM3 antibodyTNNT 2 antibodyTNNT2 antibodyTNNT2_HUMAN antibodyTnTC antibodyTroponin T cardiac muscle antibodyTroponin T type 2 (cardiac) antibodyTroponin T type 2 cardiac antibodyTroponin T, cardiac muscle antibodyTroponin T2 antibodyTroponin T2 cardiac antibody
see all
References for Anti-cardiac Troponin T antibody (ab998)
ab998 has not yet been referenced specifically in any publications.
