Anti-Cardiac Troponin C antibody [7B9] (HRP) (ab8286)

Overview

  • Product nameAnti-Cardiac Troponin C antibody [7B9] (HRP)
    See all Cardiac Troponin C primary antibodies
  • Description
    Mouse monoclonal [7B9] to Cardiac Troponin C (HRP)
  • ConjugationHRP
  • Tested applicationsSuitable for: Sandwich ELISA, WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human).

  • General notes


    Reconizes TnC in binary complex with cTnI, has no cross reaction with cTnT and cTnI.

Properties

Applications

Our Abpromise guarantee covers the use of ab8286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [1A2] to Cardiac Troponin C (ab8285). Can be used as Detection antibody.
WB Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
AP Use at an assay dependent dilution.

Target

  • FunctionTroponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • Involvement in diseaseDefects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similaritiesBelongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt
  • Database links
  • Alternative names
    • tnnc1a antibody
    • Cardiac troponin C antibody
    • slow skeletal and cardiac muscles antibody
    • TN-C antibody
    • TNC antibody
    • Tnnc1 antibody
    • TNNC1_HUMAN antibody
    • TNNI3 antibody
    • Troponin C antibody
    • Troponin C slow antibody
    • Troponin C1 slow antibody
    see all

References for Anti-Cardiac Troponin C antibody [7B9] (HRP) (ab8286)

ab8286 has not yet been referenced specifically in any publications.

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