Potent β and α1 adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1, β2 and α1 adrenoceptors, respectively). Shows antihypertensive, antioxidant, antiapoptotic, anti-inflammatory and antifibrotic properties.
Store at +4°C. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Arozal W et al. Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy. ISRN Pharmacol2011:430549 (2011).
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Pönicke K et al. Differential effects of bucindolol and carvedilol on noradenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats. J Pharmacol Exp Ther301:71-6 (2002).
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