Overview

  • Product name
    Anti-Casein Kinase 1 alpha antibody [AT2E2]
    See all Casein Kinase 1 alpha primary antibodies
  • Description
    Mouse monoclonal [AT2E2] to Casein Kinase 1 alpha
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length human protein Casein Kinase 1 alpha purified from E. coli (NP_001883)

  • Positive control
    • HeLa and MCF7 cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab88079 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Predicted molecular weight: 39 kDa.
ELISA Use at an assay dependent dilution.

Target

  • Function
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization
    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Nucleus speckle. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.
  • Information by UniProt
  • Database links
  • Alternative names
    • Casein kinase 1 alpha 1 antibody
    • Casein kinase I isoform alpha antibody
    • CK1 antibody
    • CK1A antibody
    • CKI alpha antibody
    • CKI-alpha antibody
    • CKIa antibody
    • Clock regulator kinase antibody
    • Csnk1a1 antibody
    • Down regulated in lung cancer antibody
    • HLCDGP1 antibody
    • KC1A_HUMAN antibody
    • PRO2975 antibody
    see all

Images

  • All lanes : Anti-Casein Kinase 1 alpha antibody [AT2E2] (ab88079) at 1/1000 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : MCF7 cell lysate

    Lysates/proteins at 40 µg per lane.

    Secondary
    HRP conjugated goat anti-mouse IgG
    Developed using the ECL technique

    Predicted band size : 39 kDa
    Observed band size : 39 kDa

References

This product has been referenced in:
  • Lin TC  et al. The nucleolar protein NIFK promotes cancer progression via CK1a/ß-catenin in metastasis and Ki-67-dependent cell proliferation. Elife 5:N/A (2016). WB . Read more (PubMed: 26984280) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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