• Product nameAnti-CASK antibody
    See all CASK primary antibodies
  • Description
    Rabbit polyclonal to CASK
  • SpecificityAnti-CASK/Lin2 specifically recognizes human CASK/Lin2 by immunoblotting and immunoprecipitation (112 kDa). Staining of Cask/Lin2 by immunoblotting is inhibited by the immunizing peptide. Additional bands may be detected in some extract preparations.
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide:


    conjugated to KLH, corresponding to amino acids 393-409 of Human CASK.

  • General notesStorage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.



Our Abpromise guarantee covers the use of ab11343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Detects a band of approximately 112 kDa.
IP Use a concentration of 5 - 10 µg/ml.


  • FunctionMultidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
  • Tissue specificityUbiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
  • Involvement in diseaseDefects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK) [MIM:300749]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia (MICPCH Syndrome). A milder phenotype consists of mental retardation alone or associated with nystagmus.
    Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:300422]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
  • Sequence similaritiesIn the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 2 L27 domains.
    Contains 1 PDZ (DHR) domain.
    Contains 1 protein kinase domain.
    Contains 1 SH3 domain.
  • DomainThe first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.
    The protein kinase domain mediates the interaction with FCHSD2.
  • Cellular localizationNucleus. Cytoplasm. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAGH39 antibody
    • Caki antibody
    • Calcium/calmodulin dependent serine protein kinase antibody
    • Calcium/calmodulin dependent serine protein kinase (MAGUK family) antibody
    • Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase antibody
    • Calcium/calmodulin-dependent serine protein kinase antibody
    • CAMGUK antibody
    • CAMGUK protein antibody
    • CAMGUK, drosophila, homolog of antibody
    • casK antibody
    • CMG antibody
    • CSKP_HUMAN antibody
    • DXPri1 antibody
    • DXRib1 antibody
    • FGS4 antibody
    • FLJ22219 antibody
    • FLJ31914 antibody
    • hCASK antibody
    • LIN 2 antibody
    • Lin 2 homolog antibody
    • LIN2 antibody
    • Lin2 homolog antibody
    • MICPCH antibody
    • MRXSNA antibody
    • Pals3 antibody
    • Peripheral plasma membrane protein CASK antibody
    • Protein lin-2 homolog antibody
    • TNRC8 antibody
    • Trinucleotide repeat containing 8 antibody
    • Vertebtate LIN2 homolog antibody
    see all

References for Anti-CASK antibody (ab11343)

ab11343 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Human Cell lysate - whole cell (HeLa cells)
Gel Running Conditions Reduced Denaturing (7.5% SDS PAGE gel)
Loading amount 30 µg
Specification HeLa cells
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

Mr. Yupen Chung

Verified customer

Submitted Jan 30 2016

Application Western blot
Loading amount 25 µg
Gel Running Conditions Reduced Denaturing (10 % SDS PAGE gel)
Sample Human Cell lysate - whole cell (HeLa cells)
Specification HeLa cells
Blocking step BSA as blocking agent for 1 hour(s) and 30 minute(s) · Concentration: 5% · Temperature: 25°C

Abcam user community

Verified customer

Submitted May 23 2013