Overview

  • Product nameAnti-CASK antibody
    See all CASK primary antibodies
  • Description
    Rabbit polyclonal to CASK
  • SpecificityBy Western blot, this antibody detects a 112 kDa protein representing CASK from AtT20 cell lysate. Immunohistochemical staining of CASK in mouse brain with this antibody results in staining of the choroid plexus.
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CASK aa 578-592.
    Sequence:

    CERDSPSTSRQSPAN


    (Peptide available as ab4961)

  • Positive control
    • WB: AtT20 cell lysate IHC: mouse brain

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab3383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 105 kDa.Can be blocked with CASK peptide (ab4961).

Target

  • FunctionMultidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
  • Tissue specificityUbiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
  • Involvement in diseaseDefects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK) [MIM:300749]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia (MICPCH Syndrome). A milder phenotype consists of mental retardation alone or associated with nystagmus.
    Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:300422]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
  • Sequence similaritiesIn the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 2 L27 domains.
    Contains 1 PDZ (DHR) domain.
    Contains 1 protein kinase domain.
    Contains 1 SH3 domain.
  • DomainThe first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.
    The protein kinase domain mediates the interaction with FCHSD2.
  • Cellular localizationNucleus. Cytoplasm. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAGH39 antibody
    • Caki antibody
    • Calcium/calmodulin dependent serine protein kinase antibody
    • Calcium/calmodulin dependent serine protein kinase (MAGUK family) antibody
    • Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase antibody
    • Calcium/calmodulin-dependent serine protein kinase antibody
    • CAMGUK antibody
    • CAMGUK protein antibody
    • CAMGUK, drosophila, homolog of antibody
    • casK antibody
    • CMG antibody
    • CSKP_HUMAN antibody
    • DXPri1 antibody
    • DXRib1 antibody
    • FGS4 antibody
    • FLJ22219 antibody
    • FLJ31914 antibody
    • hCASK antibody
    • LIN 2 antibody
    • Lin 2 homolog antibody
    • LIN2 antibody
    • Lin2 homolog antibody
    • MICPCH antibody
    • MRXSNA antibody
    • Pals3 antibody
    • Peripheral plasma membrane protein CASK antibody
    • Protein lin-2 homolog antibody
    • TNRC8 antibody
    • Trinucleotide repeat containing 8 antibody
    • Vertebtate LIN2 homolog antibody
    see all

Anti-CASK antibody images



  • Predicted band size : 105 kDa

    Western blot detection of CASK on AtT20 cell lysate using ab3383.

References for Anti-CASK antibody (ab3383)

This product has been referenced in:
  • Ojeh N  et al. The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J Cell Sci 121:2705-17 (2008). IHC ; Mouse, Rat . Read more (PubMed: 18664494) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"