Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab4961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human CASK, catalog ab3383. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • CAGH39
    • Caki
    • Calcium/calmodulin dependent serine protein kinase
    • Calcium/calmodulin dependent serine protein kinase (MAGUK family)
    • Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase
    • Calcium/calmodulin-dependent serine protein kinase
    • CAMGUK
    • CAMGUK protein
    • CAMGUK, drosophila, homolog of
    • casK
    • CMG
    • CSKP_HUMAN
    • DXPri1
    • DXRib1
    • FGS4
    • FLJ22219
    • FLJ31914
    • hCASK
    • LIN 2
    • Lin 2 homolog
    • LIN2
    • Lin2 homolog
    • MICPCH
    • MRXSNA
    • Pals3
    • Peripheral plasma membrane protein CASK
    • Protein lin-2 homolog
    • TNRC8
    • Trinucleotide repeat containing 8
    • Vertebtate LIN2 homolog
    see all
  • FunctionMultidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
  • Tissue specificityUbiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
  • Involvement in diseaseDefects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK) [MIM:300749]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia (MICPCH Syndrome). A milder phenotype consists of mental retardation alone or associated with nystagmus.
    Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:300422]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
  • Sequence similaritiesIn the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 2 L27 domains.
    Contains 1 PDZ (DHR) domain.
    Contains 1 protein kinase domain.
    Contains 1 SH3 domain.
  • DomainThe first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.
    The protein kinase domain mediates the interaction with FCHSD2.
  • Cellular localizationNucleus. Cytoplasm. Cell membrane.
  • Information by UniProt

References for CASK peptide (ab4961)

ab4961 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab4961.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"