Anti-Caspase-1 antibody, prediluted (ab15550)

Overview

  • Product name
    Anti-Caspase-1 antibody, prediluted
    See all Caspase-1 primary antibodies
  • Description
    Rabbit polyclonal to Caspase-1, prediluted
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human Caspase-1 (internal sequence).
    Database link: P29466

  • Positive control
    • Jurkat cells and placenta.
  • General notes

    By sequence homology this antibody will recognize both the inactive and active forms of Caspase-1.

Properties

Applications

Our Abpromise guarantee covers the use of ab15550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
  • Tissue specificity
    Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • Sequence similarities
    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • Post-translational
    modifications
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CASP-1 antibody
    • CASP1 antibody
    • CASP1_HUMAN antibody
    • Caspase 1 antibody
    • Caspase-1 subunit p10 antibody
    • ICE antibody
    • IL-1 beta-converting enzyme antibody
    • IL-1BC antibody
    • IL1 beta converting enzyme antibody
    • IL1B convertase antibody
    • Interleukin 1 beta convertase antibody
    • Interleukin 1B converting enzyme antibody
    • Interleukin-1 beta convertase antibody
    • Interleukin-1 beta-converting enzyme antibody
    • p45 antibody
    see all

Images

  • ab15550 staining Caspase-1 in human placenta by Immunohistochemistry (FFPE-sections).

References

ab15550 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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We do not have any experimental data regarding the reactivity of this antibody to the active or inactive form of Caspase 1. By sequence homology this antibody will recognize both the inactive and active forms of Caspa...

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