Specificityab22684 recognises caspase-11 proenzyme (43 kD) and the large (23 kD) and small (10 kD) subunits of the mature enzyme. No crossreactivity with other caspases tested: mouse caspases-1 and 3, human caspases 1 to 10 and 14.
FunctionInvolved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses.
Tissue specificityMostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain.
Sequence similaritiesBelongs to the peptidase C14A family. Contains 1 CARD domain.
Post-translational modificationsThe two subunits are derived from the precursor sequence by a autocatalytic mechanism.
Kang MJ et al. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol178:1948-59 (2007).
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