Anti-Caspase-14 antibody [70A1426] (ab11920)

Overview

  • Product name
    Anti-Caspase-14 antibody [70A1426]
    See all Caspase-14 primary antibodies
  • Description
    Mouse monoclonal [70A1426] to Caspase-14
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human Caspase-14.
    Database link: P31944

  • Positive control
    • Mouse spleen cell extract.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    This antibody is affinity purified.
  • Clonality
    Monoclonal
  • Clone number
    70A1426
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab11920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 29.04 kDa).

Target

  • Function
    Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin.
  • Tissue specificity
    Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels.
  • Sequence similarities
    Belongs to the peptidase C14A family.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptosis related cysteine protease antibody
    • CASP 14 antibody
    • CASP-14 antibody
    • CASP14 antibody
    • Caspase 14 apoptosis related cysteine protease antibody
    • Caspase 14 precursor antibody
    • Caspase-14 subunit p10 antibody
    • Caspase14 antibody
    • CASPE_HUMAN antibody
    • MGC119078 antibody
    • MGC119079 antibody
    • MICE antibody
    • Mini ICE antibody
    see all

Anti-Caspase-14 antibody [70A1426] images

References for Anti-Caspase-14 antibody [70A1426] (ab11920)

ab11920 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. This antibody was raised against a peptide corresponding to amino acids 2-18 of caspase 14, which is right in the pro-domain or including it (depending where the caspase 14 is processed, the first putative cleavage site bein...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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