Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence

Associated products

Specifications

Our Abpromise guarantee covers the use of ab72738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Caspase-14 antibody (ab45415)

  • FormLiquid

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

    PBS pH7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

General Info

  • Alternative names
    • Apoptosis related cysteine protease
    • CASP 14
    • CASP-14
    • CASP14
    • Caspase 14 apoptosis related cysteine protease
    • Caspase 14 precursor
    • Caspase-14 subunit p10
    • Caspase14
    • CASPE_HUMAN
    • MGC119078
    • MGC119079
    • MICE
    • Mini ICE
    see all
  • FunctionBelieved to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin.
  • Tissue specificityExpressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels.
  • Sequence similaritiesBelongs to the peptidase C14A family.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

References for Caspase-14 peptide (ab72738)

ab72738 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"