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Storage instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage buffer Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg 2+ and Ca 2+), 150mM Sodium chloride, pH 7.4
Concentration information loading...
Purity Protein A purified
Purification notes The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Predicted molecular weight: 49 kDa.
1/50 - 1/100.
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Tissue specificity Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Sequence similarities Belongs to the peptidase C14A family. Contains 1 CARD domain.
Post-translational modifications The mature protease can process its own propeptide, but not that of other caspases.
Information by UniProt
CASP 2 antibody
Anti-Caspase-2 antibody images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-2 antibody (ab74127)
Immunohistochemical analysis of Caspase-2 in paraffin embedded human lung carcinoma tissue using ab74127 at a 1:50 dilution.
Left hand panel: no peptide. Right hand panel: peptide present.
Western blot - Anti-Caspase-2 antibody (ab74127)
All lanes : Anti-Caspase-2 antibody (ab74127) at 1/500 dilution Lane 1 : Extracts from HuvEc cells,
treated with Adriamycin (0.5µM, 4 hours) with no peptide Lane 2 : Extracts from HuvEc cells,
treated with Adriamycin (0.5µM, 4 hours) with peptide at 5 µg Lysates/proteins at 5 µg per lane. Predicted band size : 49 kDa Observed band size : 49 kDa
References for Anti-Caspase-2 antibody (ab74127)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"