• Product name
  • Description
    Rabbit polyclonal to Caspase 4
  • Specificity
    ab22687 recognises proenzyme (43 kDa) and the large subunit (19 kDa) and small (10 kDa) subunits of mature enzyme. For the mature enzyme, reactivity is strongest with the large subunit. No cross reactivity with other human caspases tested (1 to 3, 5 to 10, 14).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human): Caspase 4



Our Abpromise guarantee covers the use of ab22687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: 1/8000 - 1/16000. Detects bands of approximately 43, 19 and 10 kDa corresponding to the proenzyme, the large subunit and small subunits of mature enzyme, respectively (using Alkaline phosphatase-linked secondary antibody).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
    • Tissue specificity
      Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
    • Sequence similarities
      Belongs to the peptidase C14A family.
      Contains 1 CARD domain.
    • Post-translational
      The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
    • Information by UniProt
    • Database links
    • Alternative names
      • Apoptotic cysteine protease Mih1/TX antibody
      • CASP-4 antibody
      • CASP4 antibody
      • CASP4_HUMAN antibody
      • Caspase 4 apoptosis related cysteine peptidase antibody
      • Caspase-4 subunit 2 antibody
      • Caspase4 antibody
      • ICE(rel)-II antibody
      • ICE(rel)II antibody
      • ICEREL II antibody
      • ICH2 antibody
      • Mih1/TX antibody
      • Protease ICH-2 antibody
      • Protease TX antibody
      • TX antibody
      see all


    This product has been referenced in:
    • Moorwood C & Barton ER Caspase-12 ablation preserves muscle function in the mdx mouse. Hum Mol Genet 23:5325-41 (2014). Read more (PubMed: 24879640) »
    • Park GB  et al. Endoplasmic Reticulum Stress-Mediated Apoptosis of EBV-Transformed B Cells by Cross-Linking of CD70 Is Dependent upon Generation of Reactive Oxygen Species and Activation of p38 MAPK and JNK Pathway. J Immunol 185:7274-84 (2010). WB . Read more (PubMed: 21078900) »

    See all 2 Publications for this product

    Customer reviews and Q&As

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