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Storage instructions Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
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Purity Immunogen affinity purified
Purification notes This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.3 - 2 µg/ml. Detects a band of approximately 40 kDa.
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
Tissue specificity Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
Sequence similarities Belongs to the peptidase C14A family. Contains 1 CARD domain.
Post-translational modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
Information by UniProt
Apoptotic cysteine protease Mih1/TX antibody
Anti-Caspase 4 antibody images
References for Anti-Caspase 4 antibody (ab27485)
This product has been referenced in:
et al. Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death. BMC Res Notes 6:372 (2013).
Read more (PubMed: 24034452) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"