Overview

  • Product name
  • Description
    Goat polyclonal to Caspase 4
  • Specificity
    This antibody is expected to recognise all 3 isoforms of CASP4 (alpha, represented by NP_001216; gamma, NP-150649 and delta NP_150650).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Cat, Dog
  • Immunogen

    Synthetic peptide:

    CKERAEEIYPIKERN

    (Human)

  • Positive control
    • Heart and brain lysates for Western Blot.

Properties

Applications

Our Abpromise guarantee covers the use of ab27485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 2 µg/ml. Detects a band of approximately 40 kDa.

Target

  • Function
    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
  • Tissue specificity
    Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
  • Sequence similarities
    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • Post-translational
    modifications
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptotic cysteine protease Mih1/TX antibody
    • CASP-4 antibody
    • CASP4 antibody
    • CASP4_HUMAN antibody
    • Caspase 4 apoptosis related cysteine peptidase antibody
    • Caspase-4 subunit 2 antibody
    • Caspase4 antibody
    • ICE(rel)-II antibody
    • ICE(rel)II antibody
    • ICEREL II antibody
    • ICH2 antibody
    • Mih1/TX antibody
    • Protease ICH-2 antibody
    • Protease TX antibody
    • TX antibody
    see all

Images

References

This product has been referenced in:
  • Thepparit C  et al. Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death. BMC Res Notes 6:372 (2013). WB . Read more (PubMed: 24034452) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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