Anti-Caspase-6 antibody [3F52] (ab17822)

Overview

  • Product nameAnti-Caspase-6 antibody [3F52]
    See all Caspase-6 primary antibodies
  • Description
    Mouse monoclonal [3F52] to Caspase-6
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Caspase-6.
    Database link: P55212

  • EpitopeCaspase-6 prodomain
  • Positive control
    • Jurkat cells. Tonsil.

Properties

Applications

Our Abpromise guarantee covers the use of ab17822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 34 kDa. for 2 hours at room temp.
IP Use a concentration of 2 µg/ml. Denatured verified. Use Protein G.

Target

  • FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
  • Sequence similaritiesBelongs to the peptidase C14A family.
  • Post-translational
    modifications
    Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptotic protease Mch-2 antibody
    • Apoptotic protease MCH2 antibody
    • CASP-6 antibody
    • CASP6 antibody
    • CASP6_HUMAN antibody
    • Caspase 6 antibody
    • Caspase 6 apoptosis related cysteine protease antibody
    • Caspase 6, apoptosis related cysteine peptidase antibody
    • Caspase-6 subunit p11 antibody
    • Mch2 antibody
    • OTTHUMP00000162742 antibody
    • OTTHUMP00000162743 antibody
    see all

References for Anti-Caspase-6 antibody [3F52] (ab17822)

ab17822 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Both ab17822 and ab17866 recognise the pro-Caspase 6 and not the cleaved active Caspase 6. By western blotting they have both been shown to recognise a single band. I have mailed these as images in a follow up e-mail. ...

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Thank you for your enquiry. I have been through our catalogue of Caspase 6 antibodies and unfortunately I do not have details of an antibody that is specific for the active (and not the inactive) form of this target. I am in touch with the lab to de...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"