FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Sequence similaritiesBelongs to the peptidase C14A family.
Post-translational modificationsCleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
Proximity Ligation Analysis (PLA) of protein-protein interactions between CASP6 and APP. ab103570 at 1:200 dilution staining HeLa cells with anti-APP mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.
References for Anti-Caspase-6 antibody (ab103570)
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