The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 33 kDa.
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Use at an assay dependent concentration.
FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Sequence similaritiesBelongs to the peptidase C14A family.
Post-translational modificationsCleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
ab118504, at 5 µg/ml, staining Caspase-6 in formalin-fixed, paraffin-embedded Human Skeletal Muscle tissue by Immunohistochemistry using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
ab118504, at 5 µg/ml, staining Caspase-6 in formalin-fixed, paraffin-embedded Human Kidney tissue by Immunohistochemistry using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
References for Anti-Caspase-6 antibody (ab118504)
has not yet been referenced specifically in any publications.
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