Synthetic peptide corresponding to Rat Caspase-6 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). Synthetic peptide derived from the carboxy-terminal sequence of p18, the large subunit of rat caspase-6 Database link: P55212
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution.
1/1000. Predicted molecular weight: 20 kDa.
FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Sequence similaritiesBelongs to the peptidase C14A family.
Post-translational modificationsCleavages by caspase-3, caspase-8 or -10 generate the two active subunits.