FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Sequence similaritiesBelongs to the peptidase C14A family.
Post-translational modificationsCleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
ab63487, at 1:50 dilution, staining Caspase-6 in paraffin embedded human breast carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.
Western blot - Anti-Caspase-6 antibody (ab63487)
All lanes : Anti-Caspase-6 antibody (ab63487) at 1/500 dilution
Lane 1 : A431 cell extracts Lane 2 : A431 cell extracts with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size : 33 kDa Observed band size : 33 kDa Additional bands at : 25 kDa,30 kDa. We are unsure as to the identity of these extra bands.
References for Anti-Caspase-6 antibody (ab63487)
has not yet been referenced specifically in any publications.
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