Overview

  • Product nameAnti-Caspase-7 antibody
    See all Caspase-7 primary antibodies
  • Description
    Rabbit polyclonal to Caspase-7
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human Caspase-7 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Database link: P55210

  • Positive control
    • Skeletal muscle cell lysate. Colon or skin tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab109705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 34 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-
    -Gly-217' bond. Overexpression promotes programmed cell death.
  • Tissue specificityHighly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
  • Sequence similaritiesBelongs to the peptidase C14A family.
  • Post-translational
    modifications
    Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptotic protease Mch-3 antibody
    • Apoptotic protease MCH3 antibody
    • CASP-7 antibody
    • CASP7 antibody
    • CASP7_HUMAN antibody
    • Caspase 7 antibody
    • Caspase 7 apoptosis related cysteine peptidase antibody
    • Caspase-7 subunit p11 antibody
    • Caspase7 antibody
    • CMH 1 antibody
    • CMH-1 antibody
    • CMH1 antibody
    • ICE LAP3 antibody
    • ICE-LAP3 antibody
    • ICE-like apoptotic protease 3 antibody
    • LICE2 antibody
    • MCH3 antibody
    see all

Anti-Caspase-7 antibody images

  • Lane 1 : Anti-Caspase-7 antibody (ab109705) at 0.5 µg/ml
    Lane 2 : Anti-Caspase-7 antibody (ab109705) at 1 µg/ml

    Lane 1 : Human skeletal muscle cell lysate
    Lane 2 : Human skeletal muscle cell lysate


    Predicted band size : 34 kDa
  • ab109705 at 5 µg/ml staining Caspase-7 in formalin-fixed, paraffin-embedded Human colon tissue.

  • ab109705 at 5 µg/ml staining Caspase-7 in formalin-fixed, paraffin-embedded Human skin tissue.

References for Anti-Caspase-7 antibody (ab109705)

ab109705 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"