Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39730 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Caspase-7 antibody (ab25900)

    Western blot

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: PBS, 0.1% bovine serum albumin, pH 7.2

General Info

  • Alternative names
    • Apoptotic protease Mch-3
    • Apoptotic protease MCH3
    • CASP-7
    • CASP7
    • CASP7_HUMAN
    • Caspase 7
    • Caspase 7 apoptosis related cysteine peptidase
    • Caspase-7 subunit p11
    • Caspase7
    • CMH 1
    • CMH-1
    • CMH1
    • ICE LAP3
    • ICE-LAP3
    • ICE-like apoptotic protease 3
    • LICE2
    • MCH3
    see all
  • FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-
    -Gly-217' bond. Overexpression promotes programmed cell death.
  • Tissue specificityHighly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
  • Sequence similaritiesBelongs to the peptidase C14A family.
  • Post-translational
    modifications
    Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Caspase-7 peptide (ab39730)

ab39730 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab39730.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"