Overview

  • Product name
  • Description
    Rabbit polyclonal to Caspr2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 287-633 of Human Caspr2.

  • Positive control
    • 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji and mouse brain lysates; HeLa cells.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.75% Glycine, 1.21% Tris, 10% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab153856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000 - 1/20000. Predicted molecular weight: 148 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.
  • Tissue specificity
    Predominantly expressed in nervous system.
  • Involvement in disease
    Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
    Genetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
    Note=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.
  • Sequence similarities
    Belongs to the neurexin family.
    Contains 2 EGF-like domains.
    Contains 1 F5/8 type C domain.
    Contains 1 fibrinogen C-terminal domain.
    Contains 4 laminin G-like domains.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AUTS15 antibody
    • CDFE antibody
    • Cell recognition molecule Caspr2 antibody
    • CNTNAP2 antibody
    • CNTP2 antibody
    • CNTP2_HUMAN antibody
    • Contactin-associated protein-like 2 antibody
    • Homolog of Drosophila neurexin IV antibody
    • NRXN4 antibody
    • PTHSL1 antibody
    see all

Images

  • Anti-Caspr2 antibody (ab153856) at 1/5000 dilution + Molt-4 whole cell lysate at 30 µg

    Predicted band size: 148 kDa



    5% SDS PAGE
  • Anti-Caspr2 antibody (ab153856) at 1/10000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 148 kDa



    5% SDS PAGE
  • Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling Caspr2 with ab153856 at 1/200 dilution. Lower panel is merged with DNA probe.

References

ab153856 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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