Overview

  • Product nameAnti-Cathepsin D antibody, prediluted
    See all Cathepsin D primary antibodies
  • Description
    Rabbit polyclonal to Cathepsin D, prediluted
  • Tested applicationsSuitable for: IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Cathepsin D isolated from human liver.

Properties

Applications

Our Abpromise guarantee covers the use of ab925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
IHC-Fr
  • Application notesThis antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections.
    No further titration is required.
    We suggest an incubation period of 30-60 minutes at room temperature.
    However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user.
  • Target

    • FunctionAcid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
    • Tissue specificityExpressed in the aorta extrcellular space (at protein level).
    • Involvement in diseaseCeroid lipofuscinosis, neuronal, 10
    • Sequence similaritiesBelongs to the peptidase A1 family.
      Contains 1 peptidase A1 domain.
    • Post-translational
      modifications
      N- and O-glycosylated.
    • Cellular localizationLysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
    • Information by UniProt
    • Database links
    • Alternative names
      • CatD antibody
      • CATD_HUMAN antibody
      • Cathepsin D heavy chain antibody
      • CD antibody
      • Ceroid lipofuscinosis neuronal 10 antibody
      • CLN10 antibody
      • CPSD antibody
      • ctsd antibody
      • Epididymis secretory sperm binding protein Li 130P antibody
      • HEL S 130P antibody
      • Lysosomal aspartyl peptidase antibody
      • Lysosomal aspartyl protease antibody
      • MGC2311 antibody
      see all

    References for Anti-Cathepsin D antibody, prediluted (ab925)

    This product has been referenced in:
    • Zheng X  et al. Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy. Biochim Biophys Acta 1783:2294-300 (2008). Read more (PubMed: 18775751) »

    See 1 Publication for this product

    Product Wall

    Thank you for the details that you have provided and for your patience. Are you using a home made kit to stain this antibody with? This may not be as sensitive as a commercial kit, such as Dako's or Power Vision. At this point I would suggest increasin...

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    Thanks for your email. If you continue to experience difficulty with ab925 in IHC, please let me know. Just answer the questions below, and also include the lot number that you received (located on the vial), and the Abcam order number or purchase orde...

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    Thank you for your enquiry. The concentration is 0.10 mg/ml. Please note that this antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections and no further titratio...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"