Overview

  • Product name
  • Description
    Rabbit polyclonal to Cathepsin G
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide based on the propeptide domain and the N terminus of active human cathepsin G

Properties

Applications

Our Abpromise guarantee covers the use of ab49854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 29 kDa. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
    • Sequence similarities
      Belongs to the peptidase S1 family.
      Contains 1 peptidase S1 domain.
    • Cellular localization
      Cell surface.
    • Information by UniProt
    • Database links
    • Alternative names
      • CATG antibody
      • CATG_HUMAN antibody
      • Cathepsin G antibody
      • Cathepsin G precursor antibody
      • CathepsinG antibody
      • CG antibody
      • Ctsg antibody
      • CTSG protein antibody
      • MGC23078 antibody
      see all

    Images

    • All lanes : Anti-Cathepsin G antibody (ab49854) at 1/1000 dilution

      Lane 1 : Human Cathepsin G at 0.01 µg
      Lane 2 : Human Cathepsin G at 0.005 µg
      Lane 3 : Human Cathepsin G at 0.002 µg


      Predicted band size : 29 kDa
      Observed band size : 24,25,29 kDa (why is the actual band size different from the predicted?)

    References

    This product has been referenced in:
    • Arastu-Kapur S  et al. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res 17:2734-43 (2011). WB ; Human . Read more (PubMed: 21364033) »
    • Dabek M  et al. Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis. Am J Pathol 175:207-14 (2009). WB ; Human . Read more (PubMed: 19528350) »

    See all 2 Publications for this product

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    There are currently no Customer reviews or Questions for ab49854.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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