Specificityab49892 recognizes all three forms of Cathepsin K (but does not see the 288 amino acid form as well as the other two forms, due to a partial deletion of the sequence).
We have a range of domain specific antibodies for this target. For a full list please see all Cathepsin K antibodies.
FunctionClosely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Tissue specificityPredominantly expressed in osteclasts (bones).
Involvement in diseaseDefects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.
Sequence similaritiesBelongs to the peptidase C1 family.
References for Anti-Cathepsin K antibody (ab49892)
This product has been referenced in:
Singh SR et al. Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? Am J Physiol Lung Cell Mol Physiol299:L169-83 (2010).
Read more (PubMed: 20435685) »