Anti-Cathepsin K antibody - Catalytic domain (ab49893)

Overview

  • Product name
    Anti-Cathepsin K antibody - Catalytic domain
    See all Cathepsin K primary antibodies
  • Description
    Rabbit polyclonal to Cathepsin K - Catalytic domain
  • Specificity
    ab49893 recognizes all three forms of Cathepsin K (but does not see the 258 amino acid form as well as the other two forms, due to a partial deletion of the sequence).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide based on the catalytic domain of human Cathepsin K.

Properties

Applications

Our Abpromise guarantee covers the use of ab49893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 37 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates.

Target

  • Function
    Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
  • Tissue specificity
    Predominantly expressed in osteclasts (bones).
  • Involvement in disease
    Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.
  • Sequence similarities
    Belongs to the peptidase C1 family.
  • Cellular localization
    Lysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cathepsin K antibody
    • Cathepsin O antibody
    • Cathepsin O1 antibody
    • Cathepsin O2 antibody
    • Cathepsin X antibody
    • CATK_HUMAN antibody
    • CTS02 antibody
    • Ctsk antibody
    • CTSO antibody
    • CTSO1 antibody
    • CTSO2 antibody
    • MGC23107 antibody
    • PKND antibody
    • PYCD antibody
    see all

Anti-Cathepsin K antibody - Catalytic domain images

  • All lanes : Anti-Cathepsin K antibody - Catalytic domain (ab49893) at 1/1000 dilution

    Lane 1 : r-Human Cathepsin K at 0.04 µg
    Lane 2 : r-Human Cathepsin K at 0.02 µg
    Lane 3 : r-Human Cathepsin K at 0.01 µg
    Lane 4 : r-Human Cathepsin K at 0.004 µg
    Lane 5 : r-Human Cathepsin K at 0.002 µg


    Predicted band size : 37 kDa

References for Anti-Cathepsin K antibody - Catalytic domain (ab49893)

ab49893 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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