The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 4 µg/ml. Predicted molecular weight: 42 kDa.
Use a concentration of 20 - 30 µg/ml.
FunctionClosely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Tissue specificityPredominantly expressed in osteoclasts (bones).
Involvement in diseasePycnodysostosis
Sequence similaritiesBelongs to the peptidase C1 family.