This fast track antibody is not yet fully characterized. It is subject to these terms and conditions


  • Product nameAnti-Cav2.3 antibody
  • Description
    Rabbit polyclonal to Cav2.3

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Species reactivity

    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 2200 to the C-terminus of Rat Cav2.3.

    (Peptide available as ab66709.)



Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

Application Abreviews Notes
ELISA Use at an assay dependent dilution. This antibody gave a positive result in ELISA against the immunizing peptide (ab66709).


  • FunctionVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
  • Tissue specificityExpressed in neuronal tissues and in kidney.
  • Sequence similaritiesBelongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.
    Contains 1 EF-hand domain.
  • DomainEach of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • alpha-1 polypeptide antibody
    • BII antibody
    • Brain calcium channel II antibody
    • CAC 1E antibody
    • CAC1E antibody
    • CAC1E_HUMAN antibody
    • CACH 6 antibody
    • CACH6 antibody
    • CACNA1E antibody
    • Cacnl1 a6 antibody
    • CACNL1A6 antibody
    • Calcium channel antibody
    • Calcium channel, L type, alpha 1 polypeptide, isoform 6 antibody
    • calcium channel, R type antibody
    • Cav 2.3 antibody
    • Cchra 1 antibody
    • Cchra1 antibody
    • isoform 6 antibody
    • L type antibody
    • Voltage dependent R type calcium channel subunit alpha 1E antibody
    • Voltage gated calcium channel subunit alpha Cav2.3 antibody
    • Voltage-dependent R-type calcium channel subunit alpha-1E antibody
    • Voltage-gated calcium channel subunit alpha Cav2.3 antibody
    see all

Anti-Cav2.3 antibody images

This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

  • ICC/IF image of ab63705 stained PC12 cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal Goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab63705, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 Goat anti-Rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 100% Methanol fixed (5 min) PC12 cells at 1µg/ml.

References for Anti-Cav2.3 antibody (ab63705)

ab63705 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (PFA perfusion fixed frozen sections)
Sample Rat Tissue sections (Brain)
Specification Brain
Fixative Paraformaldehyde

Dr. Sophie Pezet

Verified customer

Submitted Sep 08 2010