Overview

  • Product nameCAY10626
  • Description
    Potent PI3Kα/mTOR inhibitor
  • Biological descriptionPotent, dual PI3Kα/mTOR inhibitor (IC50 values are 0.9 and 0.6 nM at PI3Kα and mTOR, respectively). Inhibits tumor cell growth, suppresses phosphorylation of downstream targets of PI3Kα and mTOR in vitro and promotes tumor regression in vivo.
  • Purity> 98%

Properties

  • Chemical nameN-[2-(Dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]benzamide
  • Molecular weight624.66
  • Chemical structureChemical Structure
  • Molecular formulaC31H35F3N8O3
  • CAS Number1202884-94-3
  • Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=C(NC1=CC=C(C(N(C)CCN(C)C)=O)C=C1)NC2=CC=C(C3=NC(N4CCOCC4)=C(C=CN5CC(F)(F)F)C5=N3)C=C2
  • Source

    Synthetic

  • Research areas

    Applications

    Our Abpromise guarantee covers the use of ab120903 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    CAY10626 images

    • ab81283 staining AKT1 (phospho S473) in PC3 cells treated with CAY10626 (ab120903), by ICC/IF. Decrease of AKT1 (phospho S473) expression correlates with increased concentration of CAY10626, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120903 (CAY10626) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab81283 (1/100) dilution was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for CAY10626 (ab120903)

    This product has been referenced in:
    • Chen Z  et al. Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors. J Med Chem 53:3169-82 (2010). Read more (PubMed: 20334367) »
    • Rameh LE & Cantley LC The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274:8347-50 (1999). Read more (PubMed: 10085060) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"