The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 54 kDa).
Use a concentration of 3.75 µg/ml.
Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Expressed in epithelial cell line. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
Belongs to the MICU1 family. Contains 2 EF-hand domains.
The EF-hand domains are required for mitochondrial calcium homeostasis function.