Overview

  • Product nameAnti-CBFA2T3 antibody
    See all CBFA2T3 primary antibodies
  • Description
    Rabbit polyclonal to CBFA2T3
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from internal sequence of Human CBFA2T3.

  • Positive control
    • Human brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab110823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionFunctions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
    Isoform 2 functions as an A-kinase-anchoring protein.
  • Tissue specificityWidely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
  • Involvement in diseaseNote=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
  • Sequence similaritiesBelongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • Cellular localizationNucleus > nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm and Nucleus > nucleoplasm. Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cbfa2t3 antibody
    • Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody
    • ETO2 antibody
    • hMTG16 antibody
    • hMTG16a antibody
    • hMTG16b antibody
    • MTG16 antibody
    • MTG16_HUMAN antibody
    • MTG8 related gene 2 antibody
    • MTG8 related protein MTG16a antibody
    • MTG8 related protein MTG16b antibody
    • MTG8-related protein 2 antibody
    • MTGR2 antibody
    • Myeloid translocation gene 8 and 16b antibody
    • Myeloid translocation gene on chromosome 16 protein antibody
    • Protein CBFA2T3 antibody
    • Zinc finger MYND domain-containing protein 4 antibody
    • ZMYND4 antibody
    see all

Anti-CBFA2T3 antibody images

  • ab110823, at 1/50 dilution, staining CBFA2T3 in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

References for Anti-CBFA2T3 antibody (ab110823)

ab110823 has not yet been referenced specifically in any publications.

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