Overview

  • Product name
  • Description
    Rabbit polyclonal to CBFA2T3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 450 - 550 of Human CBFA2T3.

    (Peptide available as ab101723.)

  • Positive control
    • This antibody gave a positive signal in the following lysates: Spleen (Human) Tissue Lysate; Bone Marrow (Human) Tissue Lysate; Thymus (Human) Tissue Lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab87159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 mg/ml. Detects a band of approximately 71 kDa (predicted molecular weight: 71 kDa).

Target

  • Function
    Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
    Isoform 2 functions as an A-kinase-anchoring protein.
  • Tissue specificity
    Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
  • Involvement in disease
    Note=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
  • Sequence similarities
    Belongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • Cellular localization
    Nucleus > nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm and Nucleus > nucleoplasm. Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cbfa2t3 antibody
    • Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody
    • ETO2 antibody
    • hMTG16 antibody
    • hMTG16a antibody
    • hMTG16b antibody
    • MTG16 antibody
    • MTG16_HUMAN antibody
    • MTG8 related gene 2 antibody
    • MTG8 related protein MTG16a antibody
    • MTG8 related protein MTG16b antibody
    • MTG8-related protein 2 antibody
    • MTGR2 antibody
    • Myeloid translocation gene 8 and 16b antibody
    • Myeloid translocation gene on chromosome 16 protein antibody
    • Protein CBFA2T3 antibody
    • Zinc finger MYND domain-containing protein 4 antibody
    • ZMYND4 antibody
    see all

Images

  • All lanes : Anti-CBFA2T3 antibody (ab87159) at 1 µg/ml

    Lane 1 : Human spleen tissue lysate - total protein (ab29699)
    Lane 2 : Bone Marrow (Human) Tissue Lysate - adult normal tissue
    Lane 3 : Human thymus tissue lysate - total protein (ab30146)

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 71 kDa
    Observed band size : 71 kDa


    Exposure time : 30 seconds

References

ab87159 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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