• Product nameAnti-CBLN1 antibody
    See all CBLN1 primary antibodies
  • Description
    Rabbit polyclonal to CBLN1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human CBLN1 (internal sequence). A 15 amino acid synthetic peptide from the middle of human CBLN1.

  • Positive control
    • Human prostate tissue.


Associated products


Our Abpromise guarantee covers the use of ab64184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 21 kDa.
IHC-P Use a concentration of 10 µg/ml.


  • FunctionRequired for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion.
    The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.
  • Tissue specificityIn the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
  • Sequence similaritiesContains 1 C1q domain.
  • Developmental stageLow at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.
  • Post-translational
    The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.
  • Cellular localizationSecreted. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • [des-Ser1]-cerebellin antibody
    • CBLN 1 antibody
    • CBLN1 antibody
    • CBLN1_HUMAN antibody
    • CER antibody
    • Cerebellin 1 antibody
    • Cerebellin 1 precursor antibody
    • Cerebellin1 antibody
    • Precerebellin antibody
    see all

Anti-CBLN1 antibody images

  • ab64184 (10ug/ml) staining human CBLN1 in human prostate tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

References for Anti-CBLN1 antibody (ab64184)

This product has been referenced in:
  • Muguruma K  et al. Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci 13:1171-80 (2010). Mouse . Read more (PubMed: 20835252) »

See 1 Publication for this product

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In answer to your questions:

1. Regarding ab36909 Precerebellin antibody

Based on the immunogen sequence, this antibody should detect precerebellin and cerebellin-1 (precerebellin without the...

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