• Product nameAnti-CBLN1 antibody
    See all CBLN1 primary antibodies
  • Description
    Rabbit polyclonal to CBLN1
  • Specificityab92526 detects endogenous levels of total CBLN1 protein.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from an internal sequence of Human CBLN1.

  • Positive control
    • HUVEC cell extracts.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab92526 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab92526 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: 1/40000.
    WB: 1/500 - 1/1000. Predicted molecular weight: 21 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRequired for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion.
      The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.
    • Tissue specificityIn the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
    • Sequence similaritiesContains 1 C1q domain.
    • Developmental stageLow at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.
    • Post-translational
      The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.
    • Cellular localizationSecreted. Cell junction > synapse > postsynaptic cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • [des-Ser1]-cerebellin antibody
      • CBLN 1 antibody
      • CBLN1 antibody
      • CBLN1_HUMAN antibody
      • CER antibody
      • Cerebellin 1 antibody
      • Cerebellin 1 precursor antibody
      • Cerebellin1 antibody
      • Precerebellin antibody
      see all

    Anti-CBLN1 antibody images

    • All lanes : Anti-CBLN1 antibody (ab92526) at 1/500 dilution

      Lane 1 : HUVEC cell extracts
      Lane 2 : HUVEC cell extracts with immunising peptide at 10 µg

      Lysates/proteins at 30 µg per lane.

      Predicted band size : 21 kDa

    References for Anti-CBLN1 antibody (ab92526)

    ab92526 has not yet been referenced specifically in any publications.

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