The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10 - 1/50.
FunctionNADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.
ab75946, at a dilution of 1/10, staining CBR1 in formalin fixed, paraffin embedded human breast carcinoma tissue by Immunohistochemistry. ab75946 was peroxidase conjugated to the secondary antibody, followed by DAB staining.
References for Anti-CBR1 antibody (ab75946)
has not yet been referenced specifically in any publications.
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