Overview

  • Product nameAnti-cbx2 antibody
    See all CBX2 primary antibodies
  • Description
    Mouse monoclonal to cbx2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: EVQNRKRGKR PRGRPRKLTA MSSCSRRSKL KVGGCAGYAD PTSQHPLGVG GRQREGLGPS GRGWHFCQQS VPLLGKQEPP FFLSLSFCCQ GPQPAESSSP , corresponding to amino acids 66-166 of Human cbx2

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
    • Involvement in diseaseDefects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:613080]. It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.
    • Sequence similaritiesContains 1 A.T hook DNA-binding domain.
      Contains 1 chromo domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cbx 2 antibody
      • CBX2 antibody
      • CBX2_HUMAN antibody
      • CDC A6 antibody
      • CDCA6 antibody
      • Cell division cycle associated 6 antibody
      • Cell division cycle associated6 antibody
      • chromobox homolog 2 (Pc class homolog, Drosophila) antibody
      • Chromobox homolog 2 antibody
      • Chromobox homolog2 antibody
      • Chromobox protein homolog 2 antibody
      • hromobox homolog 2 antibody
      • M33 antibody
      • M33 polycomb like antibody
      • MOD 2 antibody
      • MOD2 antibody
      • Modifier 3 antibody
      • Modifier3 antibody
      • Pc class homolog antibody
      • Polycomb antibody
      • SRXY5 antibody
      see all

    Anti-cbx2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57890 cbx2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-cbx2 antibody (ab57890)

    ab57890 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57890.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"