Overview

  • Product name
  • Description
    Rabbit polyclonal to CBX4
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Opossum, Chinese hamster
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 150-200 of Human CBX4 (NP_003646.2).

  • Positive control
    • Human Breast Carcinoma, Ovarian Carcinoma and Prostate Carcinoma tissues; Mouse Renal Cell Carcinoma and Teratoma tissues

Properties

Applications

Our Abpromise guarantee covers the use of ab114038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • Function
    E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
  • Tissue specificity
    Ubiquitous.
  • Pathway
    Protein modification; protein sumoylation.
  • Sequence similarities
    Contains 1 chromo domain.
  • Post-translational
    modifications
    Phosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • CBX 4 antibody
    • CBX4 antibody
    • Cbx4 chromobox homolog 4 (Drosophila Pc class) antibody
    • CBX4_HUMAN antibody
    • Chromobox homolog 4 (Pc class homolog, Drosophila) antibody
    • Chromobox homolog 4 antibody
    • Chromobox protein homolog 4 antibody
    • E3 SUMO protein ligase CBX 4 antibody
    • E3 SUMO protein ligase CBX4 antibody
    • E3 SUMO-protein ligase CBX4 antibody
    • hPc 2 antibody
    • hPc2 antibody
    • NBP 16 antibody
    • NBP16 antibody
    • NS5ATP1 binding protein 16 antibody
    • Pc 2 antibody
    • Pc class 2 homolog antibody
    • Pc class homolog antibody
    • Pc class homolog Drosophila antibody
    • PC2 antibody
    • Polycomb 2 homolog antibody
    see all

Images

  • ab114038, at 1/250 dilution, staining CBX4 in formalin-fixed, paraffin-embedded Human Breast Carcinoma tissue by Immunohistochemistry with DAB staining.
  • ab114038, at 1/250 dilution, staining CBX4 in formalin-fixed, paraffin-embedded Mouse renal cell carcinoma tissue by Immunohistochemistry with DAB staining.

References

ab114038 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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