Overview

  • Product nameAnti-cbx7 antibody
    See all cbx7 primary antibodies
  • Description
    Rabbit polyclonal to cbx7
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Cow, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within the amino acids 201-251 of Human cbx7 using the numbering given in entry NP_783640.1.

  • Positive control
    • Human Breast Carcinoma, Human Colon Carcinoma, Human Non-Small Cell Lung Cancer, Human Ovarian Carcinoma, Human Prostate Carcinoma tissues

Properties

Applications

Our Abpromise guarantee covers the use of ab123492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • RelevanceControl of cell proliferation by Polycomb group proteins (PcG) is an important facet of cellular homeostasis and its disruption can promote tumorigenesis. CBX7 is a novel PcG protein which is found to control the growth of normal cells. CBX7 is a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its localization to nuclear Polycomb bodies. CBX7 extends the lifespan of a wide range of normal human cells and immortalizes mouse fibroblasts by downregulating expression of the Ink4a/Arf locus. CBX7 does not inter-function or colocalize with Bmi1, and both can exert their actions independently of each other as shown by reverse genetics. CBX7 was highly expressed in three different prostate cancer cell lines and present at elevated levels in normal prostate. (Gil et al., 2004).
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • Cbx 7 antibody
    • CBX7 antibody
    • Chromobox homolog 7 antibody
    • Chromobox protein homolog 7 antibody

Anti-cbx7 antibody images

  • ab123492 at 1/250 dilution staining cbx7 in Human prostate carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

References for Anti-cbx7 antibody (ab123492)

ab123492 has not yet been referenced specifically in any publications.

Product Wall

Following up my previous message, the antibody ab123492 has not been tested for zebrafish reactivity and is unlikely to react, based on alignment of the immunogen with the zebrafish sequence you provided.
Please let us know if you have any other ...

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The immunogen is derived from the human CBX7 at the following UniProt entry URL:

http://www.uniprot.org/uniprot/O95931 .

Alignment of the immunogen with the sequence provided gave poor results.
Unfortunately, alignments of th...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"