The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 44 kDa.
Use a concentration of 2 - 10 µg/ml.
Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
Not expressed in blood or lymphatic endothelial cells.
Involvement in disease
Defects in CCBE1 are the cause of Hennekam lymphangiectasia-lymphedema syndrome (HLYLMP) [MIM:235510]. HLYLMP is a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation.
Belongs to the CCBE1 family. Contains 2 collagen-like domains. Contains 1 EGF-like domain.
Immunofluorescent images showing Human foreskin (left hand image) and negative control of a consecutive section (right hand image), stained with ab111495 at a 1/50 dilution. Epidermial and scattered cells in the dermis are stained green (left hand image), whereas nuclei are counter-stained blue (right hand image: negative control of a consecutive section).