Overview

  • Product name
  • Description
    Rabbit polyclonal to CCBE1
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure (>95%) recombinant Human CCBE1 (amino acids 35-406) derived from Sf9 insect cells.

  • Positive control
    • Human foreskin tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Purification notes
    Endotoxin level: < 0.1 EU/1µg of the antibody (LAL).
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 44 kDa.
ICC/IF Use a concentration of 2 - 10 µg/ml.

Target

  • Function
    Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
  • Tissue specificity
    Not expressed in blood or lymphatic endothelial cells.
  • Involvement in disease
    Defects in CCBE1 are the cause of Hennekam lymphangiectasia-lymphedema syndrome (HLYLMP) [MIM:235510]. HLYLMP is a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation.
  • Sequence similarities
    Belongs to the CCBE1 family.
    Contains 2 collagen-like domains.
    Contains 1 EGF-like domain.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • CCBE 1 antibody
    • ccbe1 antibody
    • CCBE1_HUMAN antibody
    • Collagen and calcium binding EGF domain containing protein 1 antibody
    • Collagen and calcium binding EGF domains 1 antibody
    • Collagen and calcium-binding EGF domain-containing protein 1 antibody
    • FLJ30681 antibody
    • Full of fluid protein homolog antibody
    • MGC50861 antibody
    see all

Images

  • Immunofluorescent images showing Human foreskin (left hand image) and negative control of a consecutive section (right hand image), stained with ab111495 at a 1/50 dilution. Epidermial and scattered cells in the dermis are stained green (left hand image), whereas nuclei are counter-stained blue (right hand image: negative control of a consecutive section).

References

ab111495 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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