Overview

  • Product nameAnti-CCBL1 antibody
    See all CCBL1 primary antibodies
  • Description
    Mouse monoclonal to CCBL1
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length human CCBL1 protein (AAH33685) with a 26 kDa tag.

  • Positive control
    • CCBL1 transfected 293T cell lysate; immunogen

Properties

Applications

Our Abpromise guarantee covers the use of ab76963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 48 kDa.
ELISA Use at an assay dependent dilution.

Target

  • RelevanceCCBL1 is a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity. CCBL1 catalyzes the irreversible transamination of the L-tryptophan metabolite L-kinurenine to form kynurenic acid (KA). It catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. This enzyme has a central role in the bioactivation of nephrotoxic halogenated hydrocarbons - the possibility of human exposure to these chemicals has focused interest on the CCBL1 from human kidney.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • Beta lyase antibody
    • Beta lysase, kidney antibody
    • CCBL 1 antibody
    • Cysteine conjugate beta lyase antibody
    • Cysteine conjugate beta lyase, cytoplasmic antibody
    • Cysteine conjugate beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase) antibody
    • Cysteine S conjugate beta lyase antibody
    • Cytoplasmic cysteine conjugate beta lyase antibody
    • FLJ95217 antibody
    • Glutamine phenylpyruvate aminotransferase antibody
    • Glutamine transaminase K antibody
    • GTK antibody
    • KAT1 antibody
    • KATI antibody
    • Kyneurenine aminotransferase antibody
    • Kynurenine aminotransferase I antibody
    • Kynurenine oxoglutarate transaminase 1 antibody
    • MGC29624 antibody
    • OTTHUMP00000022311 antibody
    • OTTHUMP00000022312 antibody
    see all

Anti-CCBL1 antibody images

  • Anti-CCBL1 antibody (ab76963) at 5 µg/ml + immunogen at 0.2 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

    Predicted band size : 48 kDa
    Observed band size : 68 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-CCBL1 antibody (ab76963) at 5 µg/ml

    Lane 1 : CCBL1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

    Predicted band size : 48 kDa
    Observed band size : 28 kDa (why is the actual band size different from the predicted?)

References for Anti-CCBL1 antibody (ab76963)

ab76963 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"