Overview

  • Product name
  • Description
    Rabbit polyclonal to CCDC39
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    ILDNELTETI SAQLELDKAA QDFRKIHNER QELIKQWENT IEQMQKRDGD IDNCALELAR IKQETREKEN LVKEKIKFLE SEIGNNTEFE KRISVADR, corresponding to amino acids 191-288 of Human CCDC39

  • Positive control
    • RT-4 lysate, Human pancreas tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab122269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250 - 1/500.
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly.
  • Tissue specificity
    Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis.
  • Involvement in disease
    Defects in CCDC39 are the cause of primary ciliary dyskinesia type 14 (CILD14) [MIM:613807]. A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • Sequence similarities
    Belongs to the CCDC39 family.
  • Cellular localization
    Cytoplasm > cytoskeleton > cilium axoneme. CCDC40 is required for localization to axonemes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CCD39_HUMAN antibody
    • Ccdc39 antibody
    • CILD141 antibody
    • Coiled-coil domain-containing protein 39 antibody
    • DKFZp434A128 antibody
    • FAP59 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human bronchus tissue labelling CCDC39 with ab122269. Staining shows strong positivity in cilia of respiratory epithelial cells.
  • All lanes : Anti-CCDC39 antibody (ab122269) at 1/250 dilution

    Lane 1 : RT-4 lysate
    Lane 2 : U251-MG lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

References

ab122269 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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