Anti-CCDC40 antibody (ab121727)

Overview

• Product nameAnti-CCDC40 antibody
• Description
  Rabbit polyclonal to CCDC40
• Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  antigen sequence, corresponding to amino acids 19-104 (SEGEKEGNNE SHMVSPPEKD DGQKGEEAVG STEHPEEVTT QAEAAIEEGE VETEGEAAVE GEEEAVSYGD AESEEEYYYT ETSSPE) of Human CCDC40.

  Run BLAST with Run BLAST with
• Positive control
  • Human urinary bladder tissue; RT4, U251 MG, Human liver and tonsil lysates.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferpH: 7.20
  Preservative: 0.02% Sodium azide
  Constituents: 59% PBS, 40% Glycerol
• Concentration information loading...
• PurityImmunogen affinity purified
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • RNA Processing
  • Splicing

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Human tonsil normal tissue lysate - total protein (ab29615)
  • Human liver tissue lysate - total protein (ab29889)
  • Bladder (human) normal tissue slides (ab4287)

Applications

Target

• FunctionRequired for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39.
• Involvement in diseaseDefects in CCDC40 are the cause of primary ciliary dyskinesia type 15 (CILD15) [MIM:613808]. A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
• Sequence similaritiesBelongs to the CCDC40 family.
• Cellular localizationCytoplasm. Cell projection > cilium. Localizes to cytoplasm and motile cilium.

• Target information above from: UniProt accession Q4G0X9 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 55036 Human
  • Omim: 613799 Human
  • SwissProt: Q4G0X9 Human
  • Unigene: 202542 Human
• Alternative names
  • CCD40_HUMAN antibody
  • ccdc 40 antibody
  • CCDC40 antibody

  • Coiled coil domain containing 40 antibody
  • Coiled-coil domain-containing protein 40 antibody
  • FLJ20753 antibody
  • FLJ32021 antibody
  • KIAA1640 antibody

  see all