Overview

  • Product name
  • Description
    Goat polyclonal to CCDC50
  • Specificity
    This antibody is expected to recognise both reported isoforms of human CCDC50 protein.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Chimpanzee
  • Immunogen

    Synthetic peptide:

    (C)FSKSESSHKGFHYK

    , corresponding to C terminal amino acids 292-305 of Human CCDC50

Properties

Applications

Our Abpromise guarantee covers the use of ab32884 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Use at a concentration of 5 µg/ml.
    This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:32,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Involved in EGFR signaling.
    • Tissue specificity
      Isoform 1 and isoform 2 are co-expressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart.
    • Involvement in disease
      Defects in CCDC50 are the cause of deafness autosomal dominant type 44 (DFNA44) [MIM:607453]. A form of non-syndromic hearing loss. It is initially moderate and affects mainly low to mid frequencies. Later, it progresses to involve all the frequencies and leads to a profound hearing loss by the 6th decade. The onset of the hearing loss occurs in the first decade of life.
    • Post-translational
      modifications
      Phosphorylated on tyrosine residues.
    • Cellular localization
      Cytoplasm. Associated with microtubules of the cytoskeleton and mitotic apparatus.
    • Information by UniProt
    • Database links
    • Alternative names
      • C3orf6 antibody
      • C3orf6 YMER antibody
      • CCD50_HUMAN antibody
      • CCDC 50 antibody
      • Ccdc50 antibody
      • Chromosome 3 open reading frame 6 antibody
      • Coiled coil domain containing 50 antibody
      • Coiled coil domain containing protein 50 antibody
      • Coiled-coil domain-containing protein 50 antibody
      • Protein Ymer antibody
      • Ymer antibody
      • Ymer protein antibody
      see all

    Images

    • ab32884 at 5ug/ml staining CCDC50 in human pancreas tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). A AP-staining procedure was used for detection.

    References

    ab32884 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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