Overview

  • Product name
  • Description
    Rabbit polyclonal to CCDC50
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human, Chimpanzee, Monkey
    Predicted to work with: Rat, Cow, Dog
  • Immunogen

    A portion of amino acids 450-500 of human CCDC50 (NP_777568).

  • Positive control
    • Human, mouse and rat skeletal muscle lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab72082 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.05 - 0.5 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).

Target

  • Function
    Involved in EGFR signaling.
  • Tissue specificity
    Isoform 1 and isoform 2 are co-expressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart.
  • Involvement in disease
    Defects in CCDC50 are the cause of deafness autosomal dominant type 44 (DFNA44) [MIM:607453]. A form of non-syndromic hearing loss. It is initially moderate and affects mainly low to mid frequencies. Later, it progresses to involve all the frequencies and leads to a profound hearing loss by the 6th decade. The onset of the hearing loss occurs in the first decade of life.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues.
  • Cellular localization
    Cytoplasm. Associated with microtubules of the cytoskeleton and mitotic apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C3orf6 antibody
    • C3orf6 YMER antibody
    • CCD50_HUMAN antibody
    • CCDC 50 antibody
    • Ccdc50 antibody
    • Chromosome 3 open reading frame 6 antibody
    • Coiled coil domain containing 50 antibody
    • Coiled coil domain containing protein 50 antibody
    • Coiled-coil domain-containing protein 50 antibody
    • Protein Ymer antibody
    • Ymer antibody
    • Ymer protein antibody
    see all

Images

  • Lanes 1 - 2 : Anti-CCDC50 antibody (ab72082) at 0.05 µg/ml
    Lanes 3 - 4 : Anti-CCDC50 antibody (ab72082) at 0.25 µg/ml

    Lane 1 : Human skeletal muscle lysate
    Lane 2 : Human skeletal muscle lysate plus immunizing peptide
    Lane 3 : Mouse skeletal muscle lysate
    Lane 4 : Rat skeletal muscle lysate


    Predicted band size : 36 kDa
    Observed band size : 36 kDa

References

ab72082 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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