Overview

  • Product nameAnti-CCDC6 antibody
    See all CCDC6 primary antibodies
  • Description
    Mouse monoclonal to CCDC6
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: HTVGFTPPTS LTRAGMSYYN SPGLHVQHMG TSHGITRPSP RRSNSPDKFK RPTPPPSPNT QTPVQPPPPP PPPPMQPTVP SAATSQPTPS QHSAHPSSQP , corresponding to amino acids 375-475 of Human CCDC6

Properties

Applications

Our Abpromise guarantee covers the use of ab56353 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Tissue specificityUbiquitously expressed.
    • Involvement in diseaseDefects in CCDC6 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
    • DomainThe protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.
    • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. May be a cytoskeletal protein.
    • Information by UniProt
    • Database links
    • Alternative names
      • CCDC 6 antibody
      • CCDC6 antibody
      • CCDC6_HUMAN antibody
      • Coiled coil domain containing 6 antibody
      • Coiled coil domain containing protein 6 antibody
      • Coiled-coil domain-containing protein 6 antibody
      • D10S170 antibody
      • FLJ32286 antibody
      • H4 antibody
      • Papillary thyroid carcinoma encoded protein antibody
      • Papillary thyroid carcinoma-encoded protein antibody
      • Protein H4 antibody
      • PTC antibody
      • TPC antibody
      • TST 1 antibody
      • TST1 antibody
      see all

    Anti-CCDC6 antibody images



    • Predicted band size : 66 kDa
      CCDC6 antibody (ab56353) at 1ug/lane + K-562 cell lysate at 25ug/lane.

    References for Anti-CCDC6 antibody (ab56353)

    This product has been referenced in:
    • Thanasopoulou A  et al. Loss of CCDC6 affects cell cycle through impaired intra-S-phase checkpoint control. PLoS One 7:e31007 (2012). WB ; Human . Read more (PubMed: 22363533) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"