Overview

  • Product name
  • Description
    Rabbit polyclonal to CCDC98
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 400-409 of Human CCDC98 (NP_620775.2)

  • Positive control
    • Human Ovarian Carcinoma and Testicular Seminoma tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab113278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • Function
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
  • Sequence similarities
    Belongs to the FAM175 family. Abraxas subfamily.
  • Domain
    The MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.
  • Post-translational
    modifications
    Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus. Localizes at sites of DNA damage at double-strand breaks.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3830405G04Rik antibody
    • 5630400M01Rik antibody
    • ABRA1 antibody
    • ABRAXAS antibody
    • Abraxas protein antibody
    • AI506069 antibody
    • AL024423 antibody
    • AV118690 antibody
    • BRCA1-A complex subunit Abraxas antibody
    • coiled coil domain containing 98 antibody
    • Coiled-coil domain-containing protein 98 antibody
    • F175A_HUMAN antibody
    • FAM175A antibody
    • Family with sequence similarity 175 member A antibody
    • FLJ11520 antibody
    • FLJ12642 antibody
    • FLJ13614 antibody
    • Protein FAM175A antibody
    see all

Images

  • Detection of Human CCDC98 by Immunohistochemistry.
    Sample: FFPE section of Human ovarian carcinoma. ab113278 used at a dilution of 1/250. Detection: DAB staining.

References

ab113278 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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