Overview

  • Product nameAnti-CCDC98 antibody
    See all CCDC98 primary antibodies
  • Description
    Rabbit polyclonal to CCDC98
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 400-409 of Human CCDC98 (NP_620775.2)

  • Positive control
    • Human Ovarian Carcinoma and Testicular Seminoma tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab113278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • FunctionComponent of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
  • Sequence similaritiesBelongs to the FAM175 family. Abraxas subfamily.
  • DomainThe MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.
  • Post-translational
    modifications
    Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus. Localizes at sites of DNA damage at double-strand breaks.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3830405G04Rik antibody
    • 5630400M01Rik antibody
    • ABRA1 antibody
    • ABRAXAS antibody
    • Abraxas protein antibody
    • AI506069 antibody
    • AL024423 antibody
    • AV118690 antibody
    • BRCA1-A complex subunit Abraxas antibody
    • coiled coil domain containing 98 antibody
    • Coiled-coil domain-containing protein 98 antibody
    • F175A_HUMAN antibody
    • FAM175A antibody
    • Family with sequence similarity 175 member A antibody
    • FLJ11520 antibody
    • FLJ12642 antibody
    • FLJ13614 antibody
    • Protein FAM175A antibody
    see all

Anti-CCDC98 antibody images

  • Detection of Human CCDC98 by Immunohistochemistry.
    Sample: FFPE section of Human ovarian carcinoma. ab113278 used at a dilution of 1/250. Detection: DAB staining.

References for Anti-CCDC98 antibody (ab113278)

ab113278 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113278.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"